Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

18F-Labeling of Aryl-SCF3, -OCF3and -OCHF2with [18F]Fluoride

Khotavivattana, Tanatorn, Verhoog, Stefan, Tredwell, Matthew ORCID: https://orcid.org/0000-0002-4184-5611, Pfeifer, Lukas, Calderwood, Samuel, Wheelhouse, Katherine, Collier, Thomas Lee and Gouverneur, Veronique 2015. 18F-Labeling of Aryl-SCF3, -OCF3and -OCHF2with [18F]Fluoride. Angewandte Chemie International Edition 54 (34) , pp. 9991-9995. 10.1002/anie.201504665

Full text not available from this repository.

Abstract

We report that halogenophilic silver(I) triflate permits halogen exchange (halex) nucleophilic 18F‐fluorination of aryl‐OCHFCl, ‐OCF2Br and ‐SCF2Br precursors under mild conditions. This AgI‐mediated process allows for the first time access to a range of 18F‐labeled aryl‐OCHF2, ‐OCF3 and ‐SCF3 derivatives, inclusive of [18F]riluzole. The 18F‐labeling of these medicinally important motifs expands the radiochemical space available for PET applications.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Publisher: Wiley
ISSN: 1433-7851
Last Modified: 04 Nov 2022 12:11
URI: https://orca.cardiff.ac.uk/id/eprint/122210

Citation Data

Cited 72 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item