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18F-Labeling of Aryl-SCF3, -OCF3and -OCHF2with [18F]Fluoride

Khotavivattana, Tanatorn, Verhoog, Stefan, Tredwell, Matthew ORCID:, Pfeifer, Lukas, Calderwood, Samuel, Wheelhouse, Katherine, Collier, Thomas Lee and Gouverneur, Veronique 2015. 18F-Labeling of Aryl-SCF3, -OCF3and -OCHF2with [18F]Fluoride. Angewandte Chemie International Edition 54 (34) , pp. 9991-9995. 10.1002/anie.201504665

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We report that halogenophilic silver(I) triflate permits halogen exchange (halex) nucleophilic 18F‐fluorination of aryl‐OCHFCl, ‐OCF2Br and ‐SCF2Br precursors under mild conditions. This AgI‐mediated process allows for the first time access to a range of 18F‐labeled aryl‐OCHF2, ‐OCF3 and ‐SCF3 derivatives, inclusive of [18F]riluzole. The 18F‐labeling of these medicinally important motifs expands the radiochemical space available for PET applications.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Publisher: Wiley
ISSN: 1433-7851
Last Modified: 04 Nov 2022 12:11

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