A ball-milling enabled Reformatsky reaction

Cao, Qun ORCID: https://orcid.org/0000-0002-1726-7225, Stark, Roderick, Fallis, Ian ORCID: https://orcid.org/0000-0001-7361-0182 and Browne, Duncan L. ORCID: https://orcid.org/0000-0002-8604-229X 2019. A ball-milling enabled Reformatsky reaction. ChemSusChem 12 (12) , pp. 2554-2557. 10.1002/cssc.201900886

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Abstract

An operationally simple one‐jar one‐step mechanochemical Reformatsky reaction using in situ generated organozinc intermediates under neat grinding conditions has been developed. Notable features are that this reaction protocol requires no solvent, no inert gases and no pre‐activation of the bulk zinc source. The developed process is demonstrated to have good substrate scope (39‐82% yield), and is effective irrespective of the morphology of the zinc source.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Chemistry
Publisher:	Wiley
ISSN:	1864-5631
Funders:	EPSRC
Date of First Compliant Deposit:	14 May 2019
Date of Acceptance:	25 April 2019
Last Modified:	07 May 2023 08:51
URI:	https://orca.cardiff.ac.uk/id/eprint/122476

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