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Methods of assessing late radiotherapy effects on bowel function

Nelson, Annmarie, Mann, Mala and Staffurth, John 2019. Methods of assessing late radiotherapy effects on bowel function. Current Opinion in Supportive and Palliative Care 13 (2) , pp. 134-141. 10.1097/SPC.0000000000000422

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Purpose of review Pelvic radiation disease in the form of chronic radiation-induced consequences of treatment is under recognized by healthcare professionals and under reported by patients. Gastrointestinal symptoms are not routinely assessed, and may not be causally associated with previous radiotherapy. These symptoms are therefore often under treated.Recent findings A literature search was conducted in Ovid Medline, which included Epub Ahead of Print, In-Process & Other Non-Indexed Citations and Ovid Embase for articles published between 2016 and April 2018. A total of 11 articles were selected for review. A wide range of patient reported outcome measure instruments are used in research and practice. Clinical symptom grading is restricted to a fewer number of tools but may not always capture issues, such as urgency, that are important to the patient. Clinician and patient concordance in the assessment of outcomes is limited. Initiatives to prompt communication of the relative risks of the late consequences of treatment and comparative effectiveness of treatments decisions are developing, as are new techniques to limit irradiation of healthy tissue.Summary Nonstandardized outcome measurement reduces the ability to aggregate toxicity and patient outcomes across clinical trials. The development of standardized screening and treatment algorithms for gastrointestinal symptoms can systematically locate and treat gastrointestinal late effects of treatment.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Academic & Student Support Service
Publisher: Lippincott, Williams & Wilkins
ISSN: 1751-4258
Date of First Compliant Deposit: 24 May 2019
Date of Acceptance: 25 February 2019
Last Modified: 26 Jul 2022 07:21

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