Paramo, Blanca, Wyatt, Sean ORCID: https://orcid.org/0000-0002-0572-234X and Davies, Alun M. ORCID: https://orcid.org/0000-0001-5841-8176 2019. Neuregulin-4 is required for the growth and elaboration of striatal medium spiny neuron dendrites. Journal of Neuropathology and Experimental Neurology 78 (8) , pp. 725-734. 10.1093/jnen/nlz046 |
Preview |
PDF
- Published Version
Available under License Creative Commons Attribution. Download (1MB) | Preview |
Abstract
Medium spiny neurons (MSNs) comprise the vast majority of neurons in the striatum. Changes in the exuberant dendrites of these widely connected neurons are associated with a multitude of neurological conditions and are caused by a variety of recreational and medicinal drugs. However, we have a poor understanding of the physiological regulators of dendrite growth and elaboration of this clinically important population of neurons. Here, we show that MSN dendrites are markedly smaller and less branched in neonatal mice that possess a homozygous null mutation in the neuregulin-4 gene (Nrg4−/−) compared with wild type (Nrg4+/+) littermates. Nrg4−/− mice also had a highly significant reduction in MSN dendrite spine number in neonates and adults. The striking stunted dendrite arbor phenotype of MSNs observed in Nrg4−/− neonates was replicated in MSNs cultured from Nrg4−/− embryos and was completely rescued by soluble recombinant neuregulin-4. MSNs cultured from wild type mice coexpressed NRG4 and its receptor ErbB4. Our findings show that NRG4 is a major novel regulator of dendritic growth and arborization and spine formation in the striatum and suggest that it exerts its effects by an autocrine/paracrine mechanism.
Item Type: | Article |
---|---|
Date Type: | Publication |
Status: | Published |
Schools: | Biosciences |
Additional Information: | This is an open access article distributed under the terms of the Creative Commons CC BY license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
Publisher: | Oxford University Press |
ISSN: | 0022-3069 |
Funders: | Wellcome Trust |
Date of First Compliant Deposit: | 8 July 2019 |
Date of Acceptance: | 13 May 2019 |
Last Modified: | 05 May 2023 07:01 |
URI: | https://orca.cardiff.ac.uk/id/eprint/124064 |
Citation Data
Cited 6 times in Scopus. View in Scopus. Powered By Scopus® Data
Actions (repository staff only)
Edit Item |