Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Neuregulin-4 is required for the growth and elaboration of striatal medium spiny neuron dendrites

Paramo, Blanca, Wyatt, Sean ORCID: https://orcid.org/0000-0002-0572-234X and Davies, Alun M. ORCID: https://orcid.org/0000-0001-5841-8176 2019. Neuregulin-4 is required for the growth and elaboration of striatal medium spiny neuron dendrites. Journal of Neuropathology and Experimental Neurology 78 (8) , pp. 725-734. 10.1093/jnen/nlz046

[thumbnail of nlz046.pdf]
Preview
PDF - Published Version
Available under License Creative Commons Attribution.

Download (1MB) | Preview

Abstract

Medium spiny neurons (MSNs) comprise the vast majority of neurons in the striatum. Changes in the exuberant dendrites of these widely connected neurons are associated with a multitude of neurological conditions and are caused by a variety of recreational and medicinal drugs. However, we have a poor understanding of the physiological regulators of dendrite growth and elaboration of this clinically important population of neurons. Here, we show that MSN dendrites are markedly smaller and less branched in neonatal mice that possess a homozygous null mutation in the neuregulin-4 gene (Nrg4−/−) compared with wild type (Nrg4+/+) littermates. Nrg4−/− mice also had a highly significant reduction in MSN dendrite spine number in neonates and adults. The striking stunted dendrite arbor phenotype of MSNs observed in Nrg4−/− neonates was replicated in MSNs cultured from Nrg4−/− embryos and was completely rescued by soluble recombinant neuregulin-4. MSNs cultured from wild type mice coexpressed NRG4 and its receptor ErbB4. Our findings show that NRG4 is a major novel regulator of dendritic growth and arborization and spine formation in the striatum and suggest that it exerts its effects by an autocrine/paracrine mechanism.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Additional Information: This is an open access article distributed under the terms of the Creative Commons CC BY license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Publisher: Oxford University Press
ISSN: 0022-3069
Funders: Wellcome Trust
Date of First Compliant Deposit: 8 July 2019
Date of Acceptance: 13 May 2019
Last Modified: 05 May 2023 07:01
URI: https://orca.cardiff.ac.uk/id/eprint/124064

Citation Data

Cited 6 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item

Downloads

Downloads per month over past year

View more statistics