Phylogenetic determinants of toxin gene distribution in genomes of Brevibacillus laterosporus

Glare, Travis R., Durrant, Abigail, Berry, Colin ORCID: https://orcid.org/0000-0002-9943-548X, Palma, Leopoldo, Ormskirk, M. Marsha and Cox, Murray P. 2020. Phylogenetic determinants of toxin gene distribution in genomes of Brevibacillus laterosporus. Genomics 112 (1) , pp. 1042-1053. 10.1016/j.ygeno.2019.06.020

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Abstract

Brevibacillus laterosporus is a globally ubiquitous, spore forming bacterium, strains of which have shown toxic activity against invertebrates and microbes and several have been patented due to their commercial potential. Relatively little is known about this bacterium. Here, we examined the genomes of six published and five newly determined genomes of B. laterosporus, with an emphasis on the relationships between known and putative toxin encoding genes, as well as the phylogenetic relationships between strains. Phylogenetically, strain relationships are similar using average nucleotide identity (ANI) values and multi-gene approaches, although PacBio sequencing revealed multiple copies of the 16S rDNA gene which lessened utility at the strain level. Based on ANI values, the New Zealand isolates were distant from other isolates and may represent a new species. While all of the genomes examined shared some putative toxicity or virulence related proteins, many specific genes were only present in a subset of strains.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences
Additional Information:	Publishers website shows an Attribution 4.0 International (CC BY 4.0) for this article
Publisher:	Elsevier
ISSN:	0888-7543
Date of First Compliant Deposit:	8 July 2019
Date of Acceptance:	17 June 2019
Last Modified:	05 May 2023 18:19
URI:	https://orca.cardiff.ac.uk/id/eprint/124070

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