One-pot conversion of allylic alcohols to α-methyl ketones via iron-catalyzed isomerization-methylation

Latham, Daniel E., Polidano, Kurt, Williams, Jonathan M. J. and Morrill, Louis C. ORCID: https://orcid.org/0000-0002-6453-7531 2019. One-pot conversion of allylic alcohols to α-methyl ketones via iron-catalyzed isomerization-methylation. Organic Letters 21 (19) , pp. 7914-7918. 10.1021/acs.orglett.9b02900

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Abstract

A one-pot iron-catalyzed conversion of allylic alcohols to α-methyl ketones has been developed. This isomerization–methylation strategy utilized a (cyclopentadienone)iron(0) carbonyl complex as precatalyst and methanol as the C1 source. A diverse range of allylic alcohols undergoes isomerization–methylation to form α-methyl ketones in good isolated yields (up to 84% isolated yield).

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Chemistry Cardiff Catalysis Institute (CCI)
Publisher:	American Chemical Society
ISSN:	1523-7060
Funders:	EPSRC
Date of First Compliant Deposit:	24 October 2019
Date of Acceptance:	13 September 2019
Last Modified:	05 May 2023 10:23
URI:	https://orca.cardiff.ac.uk/id/eprint/126289

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