Longitudinal population subgroups of CRP and risk of depression in the ALSPAC birth cohort

Osimo, Emanuele F., Stochl, Jan, Zammit, Stan ORCID: https://orcid.org/0000-0002-2647-9211, Lewis, Glyn, Jones, Peter B. and Khandaker, Golam M. 2019. Longitudinal population subgroups of CRP and risk of depression in the ALSPAC birth cohort. Comprehensive Psychiatry , 152143. 10.1016/j.comppsych.2019.152143

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Abstract

Meta-analyses confirm increased circulating C-reactive protein (CRP) levels in depression. Longitudinal studies have linked one-off measurements of CRP at baseline with increased risk of developing depressive symptoms subsequently at follow-up, but studies with repeat CRP measures from the same individuals are scarce. We have examined whether longitudinal patterns of inflammation, based on three CRP measurements from childhood to early-adulthood, are associated with the risk of depression in early-adulthood in the Avon Longitudinal Study of Parents and Children, a prospective birth cohort.

Item Type:	Article
Date Type:	Published Online
Schools:	Medicine
Publisher:	WB Saunders
ISSN:	0010-440X
Date of First Compliant Deposit:	7 November 2019
Date of Acceptance:	26 October 2019
Last Modified:	02 May 2023 13:41
URI:	https://orca.cardiff.ac.uk/id/eprint/126634

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