Biocide potentiation using cinnamic phytochemicals and derivatives

Malheiro, Joana F., Maillard, Jean-Yves ORCID: https://orcid.org/0000-0002-8617-9288, Borges, Fernanda and Simões, Manuel 2019. Biocide potentiation using cinnamic phytochemicals and derivatives. Molecules 24 (21) , p. 3918. 10.3390/molecules24213918

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Abstract

Surface disinfection is of utmost importance in the prevention of bacterial infections. This study aims to assess the ability of ten phytochemicals and related derivatives as potentiators of two commonly used biocides—cetyltrimethylammonium bromide (CTAB) and lactic acid (LA). LA in combination with cinnamic, hydrocinnamic, α-methylcinnamic, and α-fluorocinnamic acids had a factional inhibitory concentration index (FICI) ≤ 1 for Escherichia coli and Staphylococcus aureus. Several phytochemicals/derivatives in combination with biocides improved the biocidal efficacy against early sessile bacteria. The most effective combination was LA with allyl cinnamate (2.98 ± 0.76 log CFU·cm−2 reduction) against E. coli. The combination with CTAB was successful for most phytochemicals/derivatives with a maximum bactericidal efficacy against sessile E. coli when combined with allyl cinnamate (2.20 ± 0.07 log CFU·cm−2 reduction) and for S. aureus when combined with α-methylcinnamic acid (1.68 ± 0.30 log CFU·cm−2 reduction). This study highlights the potential of phytochemicals and their derivatives to be used in biocide formulations

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Pharmacy
Publisher:	MDPI
ISSN:	1420-3049
Date of First Compliant Deposit:	7 November 2019
Date of Acceptance:	26 September 2019
Last Modified:	02 May 2023 16:56
URI:	https://orca.cardiff.ac.uk/id/eprint/126660

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