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Polysaccharides for protein and peptide conjugation

Ferguson, Elaine ORCID:, Varache, Mathieu ORCID:, Stokniene, Joana and Thomas, David 2019. Polysaccharides for protein and peptide conjugation. Pasut, Gianfranco and Zalipsky, Samuel, eds. Polymer-Protein Conjugates: From Pegylation and Beyond, Elsevier, pp. 421-453. (10.1016/B978-0-444-64081-9.00019-X)

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Since the 1970s, polysaccharides such as dextran, dextrin, hyaluronic acid, hydroxyethyl starch, and polysialic acid have been investigated as carriers for therapeutic protein and peptide drugs in a wide range of clinical applications. Polysaccharides possess many favorable features for the targeted delivery of protein and peptide drugs because they are biodegradable, hydrophilic, and nontoxic. Given the reported potential of nonbiodegradable polymers, such as polyethylene glycol, to induce lysosomal storage disease and induce antibody formation, the use of polysaccharides for the delivery of therapeutic proteins and peptides has become increasingly attractive. This chapter presents a historical overview of the field and explores the progress that has been made to date, using examples of conjugates from the literature. The available techniques to activate polysaccharides and purify and characterize polysaccharide–protein conjugates are reviewed. The current status, future possibilities, and barriers to the clinical translation of polysaccharide–protein conjugates are also discussed.

Item Type: Book Section
Date Type: Published Online
Status: Published
Schools: Dentistry
Publisher: Elsevier
ISBN: 9780444640819
Last Modified: 25 Nov 2022 11:41

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