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Number of items: 31.

Rizzo, Siân, Varache, Mathieu ORCID:, Sayers, Edward J. ORCID:, Jones, Arwyn T. ORCID:, Tonks, Alex ORCID:, Thomas, David W. ORCID: and Ferguson, Elaine L. ORCID: 2024. Modification of the antibiotic, colistin, with dextrin causes enhanced cytotoxicity and triggers apoptosis in myeloid leukemia. International Journal of Nanomedicine 19 , pp. 5419-5437. 10.2147/IJN.S449185

Varache, Mathieu ORCID:, Rizzo, Siân, Sayers, Edward J. ORCID:, Newbury, Lucy, Mason, Anna, Liao, Chia-Te, Chiron, Emilie, Bourdiec, Nathan, Jones, Adam, Fraser, Donald J. ORCID:, Taylor, Philip R. ORCID:, Jones, Arwyn T. ORCID:, Thomas, David W. ORCID: and Ferguson, Elaine L. ORCID: 2024. Dextrin conjugation to colistin inhibits its toxicity, cellular uptake and acute kidney injury in vivo. RSC Pharmaceutics 1 , pp. 68-79. 10.1039/D3PM00014A

Sharma, Priyasha, Richards, Charlotte ORCID:, Adams, Jennifer, Powell, Lydia ORCID:, Ferguson, Elaine ORCID:, Coutinho, Grace, Hallett, Thomas, Kulasekaran, Anuradha, Thomas, David ORCID: and Hill, Katja ORCID: 2023. In vitro antibiofilm activity of hexylresorcinol lozenges against oropharyngeal pathogens. Presented at: 2023 ERS International Congress, Milan, Italy, 9-13 September 2023. European Respiratory Journal. European Respiratory Society, 10.1183/13993003.congress-2023.PA603

Stokniene, Joana, Varache, Mathieu ORCID:, Rye, Philip D, Hill, Katja E ORCID:, Thomas, David W ORCID: and Ferguson, Elaine L ORCID: 2022. Alginate oligosaccharides enhance diffusion and activity of colistin in a mucin-rich environment. Scientific Reports 12 , 4986. 10.1038/s41598-022-08927-1

Chiron, Emilie, Varache, Mathieu ORCID:, Stokniene, Joana, Thomas, David W. ORCID: and Ferguson, Elaine L. ORCID: 2021. A physicochemical assessment of the thermal stability of dextrin–colistin conjugates. Scientific Reports 11 , 10600. 10.1038/s41598-021-89946-2

Stokniene, Joana, Powell, Lydia C. ORCID:, Aarstad, Olav A., Aachmann, Finn L., Rye, Philip D., Hill, Katja E. ORCID:, Thomas, David W. ORCID: and Ferguson, Elaine L. ORCID: 2020. Bi-functional alginate oligosaccharide–polymyxin conjugates for improved treatment of multidrug-resistant gram-negative bacterial infections. Pharmaceutics 12 (11) , 1080. 10.3390/pharmaceutics12111080

Ferguson, Elaine ORCID:, Varache, Mathieu ORCID:, Stokniene, Joana and Thomas, David 2019. Polysaccharides for protein and peptide conjugation. Pasut, Gianfranco and Zalipsky, Samuel, eds. Polymer-Protein Conjugates: From Pegylation and Beyond, Elsevier, pp. 421-453. (10.1016/B978-0-444-64081-9.00019-X)

Varache, Mathieu ORCID:, Powell, Lydia C. ORCID:, Aarstad, Olav A., Williams, Thomas L., Wenzel, Margot N. ORCID:, Thomas, David W. ORCID: and Ferguson, Elaine L. ORCID: 2019. Polymer masked-unmasked protein therapy: Identification of the active species after amylase-activation of dextrin-colistin conjugates. Molecular Pharmaceutics 16 (7) , pp. 3199-3207. 10.1021/acs.molpharmaceut.9b00393

Ferguson, Elaine L ORCID:, Naseer, Sameza, Powell, Lydia C ORCID:, Hardwicke, Joseph, Young, Fraser I ORCID:, Zhu, Bangfu, Liu, Qian, Song, Bing ORCID: and Thomas, David W. ORCID: 2018. Controlled release of Dextrin-conjugated growth factors to support growth and differentation of neural stem cells. Stem Cell Research 33 , pp. 69-78. 10.1016/j.scr.2018.10.008

Powell, Lydia C. ORCID:, Pritchard, Manon F. ORCID:, Ferguson, Elaine L. ORCID:, Powell, Kate A. ORCID:, Patel, Shree U., Rye, Phil D., Sakellakou, Stavroula-Melina, Buurma, Niklaas J. ORCID:, Brilliant, Charles D., Copping, Jack M., Menzies, Georgina E. ORCID:, Lewis, Paul D., Hill, Katja E. ORCID: and Thomas, David W. ORCID: 2018. Targeted disruption of the extracellular polymeric network of pseudomonas aeruginosa biofilms by alginate oligosaccharides. npj Biofilms and Microbiomes 4 , 13. 10.1038/s41522-018-0056-3

Scomparin, Anna, Florindo, Helena F., Tiram, Galia, Ferguson, Elaine L. ORCID: and Satchi-Fainaro, Ronit 2017. Two-step polymer- and liposome- enzyme prodrug therapies for cancer: PDEPT and PELT concepts and future perspectives. Advanced Drug Delivery Reviews 118 , pp. 52-64. 10.1016/j.addr.2017.09.011

Ferguson, Elaine L. ORCID:, Scomparin, Anna, Hailu, Hanna and Satchi-Fainaro, Ronit 2017. HPMA copolymer-phospholipase C and dextrin-phospholipase A2 as model triggers for polymer enzyme liposome therapy (PELT). Journal of drug targeting 25 (9-10) , pp. 818-828. 10.1080/1061186X.2017.1358726

Pritchard, Manon F. ORCID:, Powell, Lydia C. ORCID:, Khan, Saira, Griffiths, Peter C., Mansour, Omar T., Schweins, Ralf, Beck, Konrad ORCID:, Buurma, Niklaas J. ORCID:, Dempsey, Christopher E., Wright, Chris J., Rye, Philip D., Hill, Katja E. ORCID:, Thomas, David W. ORCID: and Ferguson, Elaine L. ORCID: 2017. The antimicrobial effects of the alginate oligomer OligoG CF-5/20 are independent of direct bacterial cell membrane disruption. Scientific Reports 7 , 44731. 10.1038/srep44731

Roberts, Jessica L., Cattoz, Beatrice, Schweins, Ralf, Beck, Konrad ORCID:, Thomas, David W. ORCID:, Griffiths, Peter C. and Ferguson, Elaine L. ORCID: 2016. In vitro evaluation of the interaction of dextrin-colistin conjugates with bacterial lipopolysaccharide. Journal of Medicinal Chemistry 59 (2) , pp. 647-654. 10.1021/acs.jmedchem.5b01521

Azzopardi, Ernest A. ORCID:, Ferguson, Elaine L. ORCID: and Thomas, David W. ORCID: 2015. Development and validation of an in vitro pharmacokinetic/pharmacodynamic model to test the antibacterial efficacy of antibiotic polymer conjugates. Antimicrobial Agents and Chemotherapy 59 (4) , pp. 1837-1843. 10.1128/AAC.03708-14

Ferguson, Elaine L. ORCID:, Azzopardi, Ernest ORCID:, Roberts, Jessica L., Walsh, Timothy R. ORCID: and Thomas, David W. ORCID: 2014. Dextrin-Colistin conjugates as a model bioresponsive treatment for multidrug resistant bacterial infections. Molecular Pharmaceutics 11 (12) , pp. 4437-4447. 10.1021/mp500584u

Azzopardi, Ernest A. ORCID:, Ferguson, Elaine Lesley ORCID: and Thomas, David William ORCID: 2014. A novel class of bioreponsive nanomedicines for localised reinstatement of bioactivity and specific targeting [Abstract]. The Lancet 383 , S9. 10.1016/S0140-6736(14)60272-5

Azzopardi, Ernest A. ORCID:, Ferguson, Elaine Lesley ORCID: and Thomas, David William ORCID: 2013. Colistin past and future: A bibliographic analysis. Journal of Critical Care 28 (2) , 219.e13-219.e19. 10.1016/j.jcrc.2012.04.008

Azzopardi, Ernest A. ORCID:, Ferguson, Elaine Lesley ORCID: and Thomas, David William ORCID: 2013. The enhanced permeability retention effect: a new paradigm for drug targeting in infection. Journal of Antimicrobial Chemotherapy 68 (2) , pp. 257-274. 10.1093/jac/dks379

Naderi, Naghmeh, Madani, Seyed Y., Ferguson, Elaine Lesley ORCID:, Mosahebi, Afshin and Seifalian, Alexander M. 2013. Carbon nanotubes in the diagnosis and treatment of malignant melanoma. Anti-Cancer Agents in Medicinal Chemistry 13 (1) , pp. 171-185. 10.2174/1871520611307010171

Azzopardi, Ernest A. ORCID:, Camilleri, Liberato, Moseley, Ryan ORCID:, Thomas, David William ORCID: and Ferguson, Elaine Lesley ORCID: 2013. Statistical characterization of succinoylated dextrin degradation behavior in human α-amylase. Journal of Carbohydrate Chemistry 32 (7) , pp. 438-449. 10.1080/07328303.2013.831434

Ferguson, Elaine Lesley ORCID:, Roberts, Jessica Louise, Moseley, Ryan ORCID:, Griffiths, Peter Charles and Thomas, David William ORCID: 2011. Evaluation of the physical and biological properties of hyaluronan and hyaluronan fragments. International Journal of Pharmaceutics 420 (1) , pp. 84-92. 10.1016/j.ijpharm.2011.08.031

Izzo, Lorella, Griffiths, Peter Charles, Nilmini, Renuka, King, Stephen M., Wallom, Kerri-Lee, Ferguson, Elaine Lesley ORCID: and Duncan, Ruth 2011. Impact of polymer tacticity on the physico-chemical behaviour of polymers proposed as therapeutics. International Journal of Pharmaceutics 408 (1-2) , pp. 213-222. 10.1016/j.ijpharm.2011.02.003

Ferguson, Elaine Lesley ORCID:, Alshame, Alshame Mohamed J. and Thomas, David William ORCID: 2010. Evaluation of hyaluronic acid-protein conjugates for polymer masked-unmasked protein therapy. International Journal of Pharmaceutics 402 (1-2) , pp. 95-102. 10.1016/j.ijpharm.2010.09.029

Ferguson, Elaine Lesley ORCID:, Richardson, Simon C. W. and Duncan, Ruth 2010. Studies on the mechanism of action of dextrin-phospholipase A2 and its suitability for use in combination therapy. Molecular Pharmaceutics 7 (2) , pp. 510-521. 10.1021/mp900232a

Ferguson, Elaine Lesley ORCID:, De Luca, Edoardo, Heenan, Richard K., King, Stephen M. and Griffiths, Peter Charles 2010. Time-Resolved Small-Angle Neutron Scattering as a Tool for Studying Controlled Release from Liposomes using Polymer-Enzyme Conjugates. Macromolecular Rapid Communications 31 (19) , pp. 1685-1690. 10.1002/marc.201000241

Ferguson, Elaine Lesley ORCID: and Duncan, Ruth 2009. Dextrin-phospholipase A2: Synthesis and evaluation as a bioresponsive anticancer conjugate. Biomacromolecules 10 (6) , pp. 1358-1364. 10.1021/bm8013022

Treetharnmathurot, Benjaporn, Dieudonné, L., Ferguson, Elaine ORCID:, Schmaljohann, Dirk, Duncan, Ruth and Wiwattanapatapee, R. 2009. Dextrin-trypsin and ST-HPMA-trypsin conjugates: Enzyme activity, autolysis and thermal stability. International Journal of Pharmaceutics 373 (1-2) , pp. 68-76. 10.1016/j.ijpharm.2009.02.008

Hardwicke, Joseph, Ferguson, Elaine Lesley ORCID:, Moseley, Ryan ORCID:, Stephens, Philip ORCID:, Thomas, David William ORCID: and Duncan, Ruth 2008. Dextrin-rhEGF conjugates as bioresponsive nanomedicines for wound repair. Journal of Controlled Release 130 (3) , pp. 275-283. 10.1016/j.jconrel.2008.07.023

Richardson, Simon C. W., Wallom, Kerri-Lee, Ferguson, Elaine Lesley ORCID:, Deacon, Simon P. E., Davies, Matthew W., Powell, Alison J., Piper, Robert C. and Duncan, Ruth 2008. The use of fluorescence microscopy to define polymer localisation to the late endocytic compartments in cells that are targets for drug delivery. Journal of Controlled Release 127 (1) , pp. 1-11. 10.1016/j.jconrel.2007.12.015

Ferguson, Elaine Lesley ORCID: 2008. Bioresponsive polymer-phospholipase A2 conjugates as novel anti-cancer agents. PhD Thesis, Cardiff University.

This list was generated on Tue Jun 18 06:30:36 2024 BST.