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Comparison of genetic liability for sleep traits among individuals with Bipolar Disorder I or II and control participants

Lewis, Katie J.S., Richards, Alexander, Karlsson, Robert, Leonenko, Ganna ORCID:, Jones, Samuel E. ORCID:, Jones, Hannah J. ORCID:, Gordon-Smith, Katherine, Forty, Liz, Escott-Price, Valentina ORCID:, Owen, Michael J. ORCID:, Weedon, Michael N., Jones, Lisa ORCID:, Craddock, Nick ORCID:, Jones, Ian ORCID:, Landén, Mikael, O'Donovan, Michael C. ORCID: and Di Florio, Arianna ORCID: 2020. Comparison of genetic liability for sleep traits among individuals with Bipolar Disorder I or II and control participants. JAMA Psychiatry 77 (3) , pp. 303-310. 10.1001/jamapsychiatry.2019.4079

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Question: Does genetic liability to insomnia, hypersomnia, and chronotype differentiate subtypes of bipolar disorder? Findings: In this case-control study of 4672 participants with bipolar disorder and 5714 control participants, individuals with bipolar disorder I had significantly greater genetic liability to longer sleep duration, whereas individuals with bipolar disorder II had significantly greater genetic liability to insomnia; these findings were replicated in an independent sample. Individuals with bipolar subtypes did not differ in genetic liability to morning or evening chronotype. Meaning: Associations between polygenic liability to insomnia and hypersomnia and clinical strata within bipolar disorder are shown in this study for the first time, to our knowledge.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Additional Information: This is an open access article distributed under the terms of the CC-BY License.
Publisher: American Medical Association (AMA)
ISSN: 2168-622X
Funders: Wellcome Trust, MRC
Date of First Compliant Deposit: 16 January 2020
Date of Acceptance: 29 September 2019
Last Modified: 25 Oct 2023 06:21

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