Genetic contributors to risk of schizophrenia in the presence of a 22q11.2 deletion

Cleynen, Isabelle, International q.DS Brain and Behavior Consortium, Engchuan, Worrawat, Hestand, Matthew S., Heung, Tracy, Holleman, Aaron M., Johnston, H. Richard, Monfeuga, Thomas, McDonald-McGinn, Donna M., Gur, Raquel E., Morrow, Bernice E., Swillen, Ann, Vorstman, Jacob A.S., Bearden, Carrie E., Chow, Eva W. C., Van den Bree, Marianne ORCID: https://orcid.org/0000-0002-4426-3254, Emanuel, Beverley S., Vermeesch, Joris R., Warren, Stephen T., Owen, Michael J. ORCID: https://orcid.org/0000-0003-4798-0862, Chopra, Pankaj, Cutler, David J., Duncan, Richard, Kotlar, Alex V., Mulle, Jennifer G., Voss, Anna J., Zwick, Michael E., Diacou, Alexander, Golden, Aaron, Guo, Tingwei, Lin, Jhih-Rong, Wang, Tao, Zhang, Zhengdong, Zhao, Yingjie, Marshall, Christian, Merico, Daniele, Jin, Andrea, Lilley, Brenna, Salmons, Harold I., Tran, Oanh, Holmans, Peter ORCID: https://orcid.org/0000-0003-0870-9412, Pardinas, Antonio ORCID: https://orcid.org/0000-0001-6845-7590, Walters, James T. R. ORCID: https://orcid.org/0000-0002-6980-4053, Demaeral, Wolfman, Boot, Erik, Butcher, Nancy J., Costain, Gregory A., Lowther, Chelsea, Evers, Rens, van Amelsvoort, Therese A. M. J., van Duin, Esther, Vingerhoets, Claudia, Breckpot, Jeroen, Devriendt, Koren, Vergaelen, Elfi, Vogels, Annick, Crowley, Blaine, McGinn, Daniel E., Moss, Edward M., Sharkus, Robert J., Unolt, Marta, Zackai, Elaine H., Calkins, Monica E., Gallagher, Robert S., Gur, Ruben C., Tang, Sunny X., Fritsch, Rosemarie, Ornstein, Claudia, Repetto, Gabriela M., Breetvelt, Elemi, Duijff, Sasja N., Fiksinski, Ania, Moss, Hayley, Niarchou, Maria ORCID: https://orcid.org/0000-0002-8855-7393, Murphy, Kieran C., Prasad, Sarah E., Daly, Eileen M., Gudbrandsen, Maria, Murphy, Clodagh M., Murphy, Declan C., Buzzanca, Antonio, Fabio, Fabio Di, Digilio, Maria C., Pontillo, Maria, Marino, Bruno, Vicari, Stefano, Coleman, Karlene, Cubells, Joseph F., Ousley, Opal Y., Carmel, Miri, Gothelf, Doron, Mekori-Domachevsky, Ehud, Michaelovsky, Elena, Weinberger, Ronnie, Weizman, Abraham, Kushan, Leila, Jalbrzikowski, Maria, Armando, Marco, Eliez, Stephan, Sandini, Corrado, Schneider, Maude, Bena, Frederique Sloan, Antshel, Kevin M., Fremont, Wanda, Kates, Wendy R., Belzeaux, Raoul, Busa, Tiffany, McCabe, Kathryn L., Philip, Nicole, Campbell, Linda E., Shashi, Vandana, Hooper, Stephen R., Schoch, Kelly, Simon, Tony J., Tassone, Flora, Arango, Celso, Fraguas, David, Garcia-Miñaur, Sixto, Morey-Canyelles, Jaume, Rosell, Jordi, Suner, Damia H., Raventos-Simic, Jasna, Epstein, Michael, Williams, Nigel M. ORCID: https://orcid.org/0000-0003-1177-6931 and Bassett, Anne S. 2021. Genetic contributors to risk of schizophrenia in the presence of a 22q11.2 deletion. Molecular Psychiatry , pp. 4496-4510. 10.1038/s41380-020-0654-3

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Abstract

Schizophrenia occurs in about one in four individuals with 22q11.2 deletion syndrome (22q11.2DS). The aim of this International Brain and Behavior 22q11.2DS Consortium (IBBC) study was to identify genetic factors that contribute to schizophrenia, in addition to the ~20-fold increased risk conveyed by the 22q11.2 deletion. Using whole-genome sequencing data from 519 unrelated individuals with 22q11.2DS, we conducted genome-wide comparisons of common and rare variants between those with schizophrenia and those with no psychotic disorder at age ≥25 years. Available microarray data enabled direct comparison of polygenic risk for schizophrenia between 22q11.2DS and independent population samples with no 22q11.2 deletion, with and without schizophrenia (total n = 35,182). Polygenic risk for schizophrenia within 22q11.2DS was significantly greater for those with schizophrenia (padj = 6.73 × 10−6). Novel reciprocal case–control comparisons between the 22q11.2DS and population-based cohorts showed that polygenic risk score was significantly greater in individuals with psychotic illness, regardless of the presence of the 22q11.2 deletion. Within the 22q11.2DS cohort, results of gene-set analyses showed some support for rare variants affecting synaptic genes. No common or rare variants within the 22q11.2 deletion region were significantly associated with schizophrenia. These findings suggest that in addition to the deletion conferring a greatly increased risk to schizophrenia, the risk is higher when the 22q11.2 deletion and common polygenic risk factors that contribute to schizophrenia in the general population are both present.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Additional Information:	Consortium authors: International 22q11.2DS Brain and Behavior Consortium
Publisher:	Springer Nature
ISSN:	1359-4184
Date of First Compliant Deposit:	15 November 2019
Date of Acceptance:	16 January 2020
Last Modified:	07 Nov 2024 02:15
URI:	https://orca.cardiff.ac.uk/id/eprint/126868

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