A simple and convenient high yielding synthesis of substituted isoindolines

Smith, Keith, El-Hiti, Gamal A., Hegazy, Amany Saber and Shalabi, Ahmed Fekri 2010. A simple and convenient high yielding synthesis of substituted isoindolines. Heterocycles 80 (2) , pp. 941-956. 10.3987/COM-09-S(S)61

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Abstract

Trifluoroacetic anhydride-induced dehydration of substituted 2-(pivaloylaminomethyl)phenyl- and 2-(dimethylaminocarbonylmethyl)phenylmethanols gives the corresponding isoindolines in excellent yields when there are aryl substituents at the methanol carbon atom.

Item Type:	Article
Status:	Published
Schools:	Chemistry
Subjects:	Q Science > QD Chemistry
Uncontrolled Keywords:	Cyclization ; Dehydration ; Heterocycle ; Substituted Benzyl-N,N-dimethylurea ; Synthesis
Publisher:	Sendai Institute of Heterocyclic Chemistry
ISSN:	0385-5414
Date of First Compliant Deposit:	30 March 2016
Last Modified:	02 Jun 2023 22:25
URI:	https://orca.cardiff.ac.uk/id/eprint/12724

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