Gaps in knowledge and future directions for the use of faecal microbiota transplant in the treatment of inflammatory bowel disease

Yalchin, Mehmet, Segal, Jonathan P, Mullish, Benjamin H, Nabil Quraishi, Mohammed, Iqbal, Tariq H, Marchesi, Julian R ORCID: https://orcid.org/0000-0002-7994-5239 and Hart, Ailsa L 2019. Gaps in knowledge and future directions for the use of faecal microbiota transplant in the treatment of inflammatory bowel disease. Therapeutic Advances in Gastroenterology 12 , pp. 1-18. 10.1177/1756284819891038

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Abstract

Faecal microbiota transplant (FMT) has now been established into clinical guidelines for the treatment of recurrent and refractory Clostridioides difficile infection (CDI). Its therapeutic application in inflammatory bowel disease (IBD) is currently at an early stage. To date, there have been four randomized controlled trials for FMT in IBD and a multitude of observational studies. However, significant gaps in our knowledge regarding optimum methods for FMT preparation, technical aspects and logistics of its administration, as well as mechanistic underpinnings, still remain. In this article, we aim to highlight these gaps by reviewing evidence and making key recommendations on the direction of future studies in this field. In addition, we provide an overview of the current evidence of potential mechanisms of FMT in treating IBD.

Item Type:	Article
Date Type:	Published Online
Status:	Published
Schools:	Biosciences
Publisher:	SAGE Publications
ISSN:	1756-283X
Date of First Compliant Deposit:	12 December 2019
Date of Acceptance:	6 November 2019
Last Modified:	04 May 2023 23:55
URI:	https://orca.cardiff.ac.uk/id/eprint/127481

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