Reduction of niridazole by metronidazole resistant and susceptible strains of Trichomonas vaginalis

Yarlett, N., Rowlands, C.C., Evans, J.C., Yarlett, N.C. and Lloyd, David ORCID: https://orcid.org/0000-0002-5656-0571 1987. Reduction of niridazole by metronidazole resistant and susceptible strains of Trichomonas vaginalis. Parasitology 94 (1) , pp. 93-99. 10.1017/S0031182000053488

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Abstract

The inhibitory effect of niridazole on hydrogen production by metronidazole-resistant (CDC-85) and susceptible (Cl-NIH) Trichomonas vaginalis strains was investigated. The results show that niridazole is more effective than metronidazole in inhibiting hydrogen production by the resistant isolate. In CDC-85 aerobic inhibition requires a 4-fold increase in metronidazole concentration compared with that required anaerobically, but the corresponding factor for niridazole is only 1·5-fold. Reduction of the drug by a hydrogenosome-enriched preparation gave rise to a multiline electron spin resonance detectable signal, which is due to a nitrogen-centred radical.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences
Publisher:	Cambridge University Press (CUP)
ISSN:	0031-1820
Last Modified:	26 Oct 2022 08:41
URI:	https://orca.cardiff.ac.uk/id/eprint/128062

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