Metronidazole-resistant clinical isolates of Trichomonas vaginalis have lowered oxygen affinities

Yarlett, N., Yarlett, N.C. and Lloyd, D. ORCID: https://orcid.org/0000-0002-5656-0571 1986. Metronidazole-resistant clinical isolates of Trichomonas vaginalis have lowered oxygen affinities. Molecular and Biochemical Parasitology 19 (2) , 111--116. 10.1016/0166-6851(86)90115-5

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Abstract

Oxygen affinities of metronidazole susceptible and resistant isolates of the parasitic flagellate protozoon Trichomonas vaginalis were determined by mass spectrometric methods. Apparent O2Km values for the respiration of non-proliferating cell suspensions were about 10-fold higher for metronidazole resistant strains than for the susceptible strains C1-NIH or NYH-286. Simultaneous monitoring of hydrogen evolution in the presence of increasing O2 tensions enabled apparent Ki values for H2 to be determined; and this function was independent of metronidazole susceptibility. Apparent O2 affinities of the hydrogenosomal and non-sedimentable fractions were determined for the strains CDC 85 (metronidazole resistant) and C1-NIH, which showed the deficiency in the O2 scavenging capacity by the resistant strain to be associated with the hydrogenosome-containing fraction.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences
Publisher:	Elsevier
ISSN:	0166-6851
Date of Acceptance:	2 December 1985
Last Modified:	26 Oct 2022 08:41
URI:	https://orca.cardiff.ac.uk/id/eprint/128064

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