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New concepts in DNA methylation

Jeltsch, Albert and Jurkowska, Renata Z. ORCID: 2014. New concepts in DNA methylation. Trends in Biochemical Sciences 39 (7) , pp. 310-318. 10.1016/j.tibs.2014.05.002

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The widely-cited model of maintenance of DNA methylation at CpG sites implies that DNA methylation is introduced by the Dnmt3 de novo DNA methyltransferases during early development, and methylation at hemimethylated CpG sites is specifically maintained by the Dnmt1 maintenance methyltransferase. However, substantial experimental evidence from the past decade indicates that this simple model needs to be revised. DNA methylation can be described by a dynamic stochastic model, in which DNA methylation at each site is determined by the local activity of DNA methyltransferases (Dnmts), DNA demethylases, and the DNA replication rate. Through the targeting and regulation of these enzymes, DNA methylation is controlled by the network of chromatin marks.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Publisher: Elsevier
ISSN: 0968-0004
Date of First Compliant Deposit: 10 January 2020
Date of Acceptance: 1 July 2014
Last Modified: 26 Oct 2022 08:49

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