A mechanochemical zinc-mediated barbier-type allylation reaction under ball-milling conditions

Yin, JieXiang, Stark, Roderick T., Fallis, Ian A. ORCID: https://orcid.org/0000-0001-7361-0182 and Browne, Duncan L. ORCID: https://orcid.org/0000-0002-8604-229X 2020. A mechanochemical zinc-mediated barbier-type allylation reaction under ball-milling conditions. Journal of Organic Chemistry 85 (4) , pp. 2347-2354. 10.1021/acs.joc.9b02876

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Abstract

A ball-milling-enabled zinc-mediated Barbier-type allylation reaction is reported. Notably, running the reaction in this manner renders it effective irrespective of the initial morphology of the zinc metal. The process is operationally simple, does not require inert atmospheres or dry solvents, and is reported over a range of aldehyde and ketone substrates; a gram-scale process is demonstrated.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Chemistry
Publisher:	American Chemical Society
ISSN:	0022-3263
Funders:	KESS
Date of First Compliant Deposit:	13 January 2020
Date of Acceptance:	20 December 2019
Last Modified:	24 Nov 2024 07:30
URI:	https://orca.cardiff.ac.uk/id/eprint/128463

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