Prenatal exposure to maternal cigarette smoking and structural properties of the human corpus callosum

Björnholm, L., Nikkinen, J., Kiviniemi, V., Niemelä, S., Drakesmith, Mark ORCID: https://orcid.org/0000-0001-8574-9560, Evans, J.C., Pike, G.B., Richer, L., Pausova, Z., Veijola, J. and Paus, T. 2020. Prenatal exposure to maternal cigarette smoking and structural properties of the human corpus callosum. NeuroImage 209 , 116477. 10.1016/j.neuroimage.2019.116477

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Abstract

Alterations induced by prenatal exposure to nicotine have been observed in experimental (rodent) studies. While numerous developmental outcomes have been associated with prenatal exposure to maternal cigarette smoking (PEMCS) in humans, the possible relation with brain structure is less clear. Here we sought to elucidate the relation between PEMCS and structural properties of human corpus callosum in adolescence and early adulthood in a total of 1,747 youth. We deployed three community-based cohorts of 446 (age 25–27 years, 46% exposed), 934 (age 12–18 years, 47% exposed) and 367 individuals (age 18–21 years, 9% exposed). A mega-analysis revealed lower mean diffusivity in the callosal segments of exposed males. We speculate that prenatal exposure to maternal cigarette smoking disrupts the early programming of callosal structure and increases the relative portion of small-diameter fibres.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Psychology
Publisher:	Elsevier
ISSN:	1053-8119
Date of First Compliant Deposit:	15 January 2020
Date of Acceptance:	18 December 2019
Last Modified:	06 May 2023 00:15
URI:	https://orca.cardiff.ac.uk/id/eprint/128589

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