Characterisation of EphA1 and its potential role in Alzheimer’s Disease

Owens, Helen Anne 2019. Characterisation of EphA1 and its potential role in Alzheimer’s Disease. PhD Thesis, Cardiff University. Item availability restricted.

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Abstract

Recent genetic evidence has identified the EphA1 gene as a susceptibility locus in Alzheimer’s disease with targeted sequencing identifying a nonsynonymous variant (P460L) within intron 1 (Vardarajan et al., 2015). EphA1 encodes the type-I transmembrane protein EphA1, a member of the Eph family of receptor tyrosine kinases. Eph receptors and their surface associated ligands, ephrins, play a role in immunity and inflammation, with inflammatory mechanisms a central component of AD neuropathology. This study aimed to characterise the WT EphA1 molecule as a means to understand the pathological potential of P460L EphA1.

Item Type:	Thesis (PhD)
Date Type:	Completion
Status:	Unpublished
Schools:	Medicine
Date of First Compliant Deposit:	12 February 2020
Last Modified:	26 Mar 2021 16:13
URI:	https://orca.cardiff.ac.uk/id/eprint/129570

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