Helmboldt, H., Rehbein, Julia and Hiersemann, M. 2004. Enantioselective synthesis of the C-14 to C-5 cyclopentane segment of jatrophane diterpenes. Tetrahedron Letters 45 (2) , pp. 289-292. 10.1016/j.tetlet.2003.10.171 |
Abstract
The enantioselective synthesis of the C-14 to C-5 cyclopentane segment of jatrophane diterpenes is reported. An Evans aldol addition, a Horner–Wadsworth–Emmons olefination and a thermal intramolecular carbonyl ene reaction of an α-keto ester served as key C/C-connecting transformations. An Evans aldol addition and a thermal intramolecular carbonyl ene reaction of an α-keto esters are key steps in the asymmetric synthesis of the C-14 to C-5 segment of jatrophane diterpenes.
Item Type: | Article |
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Date Type: | Publication |
Status: | Published |
Schools: | Chemistry |
Subjects: | Q Science > QD Chemistry |
Uncontrolled Keywords: | Diterpene; Jatrophane; Euphorbia; Total synthesis; Carbonyl ene reaction |
Publisher: | Elsevier |
ISSN: | 0040-4039 |
Last Modified: | 19 Mar 2016 22:21 |
URI: | https://orca.cardiff.ac.uk/id/eprint/13001 |
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