Altered cerebrovascular response to acute exercise in patients with Huntington’s Disease

Steventon, J., Furby, H. ORCID: https://orcid.org/0000-0002-7279-1812, Ralph, J., O'Callaghan, P., Wise, R. ORCID: https://orcid.org/0000-0003-1700-2144, Busse, M. ORCID: https://orcid.org/0000-0002-5331-5909 and Murphy, K. ORCID: https://orcid.org/0000-0002-6516-313X 2020. Altered cerebrovascular response to acute exercise in patients with Huntington’s Disease. Brain Communications 2 (1) , fcaa044. 10.1093/braincomms/fcaa044

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Abstract

Objective. To determine whether a single session of exercise is sufficient to induce cerebral adaptations in individuals with Huntington’s disease, and explore the time dynamics of any acute cerebrovascular response. Methods. In this case-control study we employed arterial-spin labelling magnetic resonance imaging in 19 HD gene-positive participants (32-65 years old, 13 males) and 19 controls (29-63 years old, 10 males) matched for age, gender, body mass index and self-reported activity levels, to measure global and regional perfusion in response to 20-minutes of moderate intensity cycling. Cerebral perfusion was measured at baseline and 15-, 40- and 60-minutes after exercise cessation. Results. Relative to baseline, cerebral perfusion increased in HD patients yet was unchanged in control participants in the precentral gyrus, middle frontal gyrus and hippocampus 40 minutes after exercise cessation (+15 to +32.5% change in HD participants, -7.7 to 0.8% change in controls). CAG repeat length predicted the change in the precentral gyrus, and the intensity of the exercise intervention predicted hippocampal perfusion change in HD participants. In both groups, exercise increased hippocampal blood flow 60-minutes after exercise cessation. Conclusions. Here we demonstrate the utility of acute exercise as a clinically sensitive experimental paradigm to modulate the cerebrovasculature. Twenty minutes of aerobic exercise induced transient cerebrovascular adaptations in the hippocampus and cortex selectively in HD participants and likely represents latent neuropathology not evident at rest.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine Cardiff University Brain Research Imaging Centre (CUBRIC)
Publisher:	OUP
ISSN:	2632-1297
Funders:	Wellcome Trust
Date of First Compliant Deposit:	26 March 2020
Date of Acceptance:	14 March 2020
Last Modified:	27 Aug 2023 17:46
URI:	https://orca.cardiff.ac.uk/id/eprint/130598

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