Natural course of Myoclonus-Dystonia in adulthood: stable motor signs but increased psychiatry

Timmers, Elze R., Peall, Kathryn J. ORCID: https://orcid.org/0000-0003-4749-4944, Dijk, Joke M., Zutt, Rodi, Tijssen, Cees C., Bergmans, Bruno, Foncke, Elisabeth M. and Tijssen, Marina A.J. 2020. Natural course of Myoclonus-Dystonia in adulthood: stable motor signs but increased psychiatry. Movement Disorders 35 (6) , pp. 1077-1078. 10.1002/mds.28033

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Abstract

Myoclonus‐dystonia (M‐D) is a rare hyperkinetic movement disorder characterized by upper body–predominant myoclonus and dystonia.1 A large proportion of cases are caused by autosomal‐dominant inherited mutations in the SGCE gene. In addition to the motor manifestations, psychiatric disorders are frequently reported.2 Several studies have suggested that they may form a primary component of the M‐D phenotype.3, 4 This study represents the first long‐term follow‐up study of both motor and psychiatric symptomatology in adults with M‐D (SGCE mutation), providing further insights into the natural history of M‐D and enabling more prognostic information.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Neuroscience and Mental Health Research Institute (NMHRI) Medicine
Publisher:	Wiley
ISSN:	0885-3185
Date of First Compliant Deposit:	27 March 2020
Date of Acceptance:	27 February 2020
Last Modified:	18 Nov 2024 00:15
URI:	https://orca.cardiff.ac.uk/id/eprint/130618

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