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Development and characterisation of acoustofluidic devices using detachable electrodes made from PCB

Mikhaylov, Roman, Wu, Fangda, Wang, Hanlin, Clayton, Aled ORCID:, Sun, Chao, Xie, Zhihua ORCID:, Liang, Dongfang, Dong, Yinhua, Yuan, Fan, Moschou, Despina, Wu, Zhenlin, Shen, Minghong, Yang, Jian ORCID:, Fu, Yong Qing, Yang, Zhiyong ORCID:, Burton, Christian, Errington, Rachel ORCID:, Wiltshire, Marie and Yang, Xin ORCID: 2020. Development and characterisation of acoustofluidic devices using detachable electrodes made from PCB. Lab on a Chip 20 (10) , pp. 1807-1814. 10.1039/C9LC01192G

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Acoustofluidics has been increasingly applied in biology, medicine and chemistry due to its versatility in manipulating fluids, cells and nano-/micro-particles. Reducing cost and time for manufacturing surface acoustic wave (SAW)-based acoustofluidic devices could facilitate rapid applications of the SAW technology and attract more researchers into this field. We present herein a novel but simple technology to form a cost-effective SAW device by stacking electrodes made from printed circuit board (PCB) and piezoelectric substrate to generate acoustic waves. PCB-based SAW devices (PCB-SAW) have been characterized and compared to the conventional SAW devices made using the cleanroom fabrication processes. The PCB-SAW devices were successfully used to manipulate microparticles within droplets and microchannels, which showed similar performance with those previously achieved using the standard SAW devices. The PCB-SAW was further used as an acoustic tweezer to precisely pattern the human lung cancer cells inside the microchannel. Cell viability tests proved that the PCB-SAW possessed good biocompatibility to be potentially applied as a cost-effective and precise tool for acoustophoresis and beyond.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Publisher: Royal Society of Chemistry
ISSN: 1473-0197
Date of First Compliant Deposit: 2 June 2020
Date of Acceptance: 3 April 2020
Last Modified: 23 May 2024 21:19

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