Novel plasmid-mediated tet(X5) gene conferring resistance to tigecycline, eravacycline, and omadacycline in a clinical Acinetobacter baumannii Isolate

Wang, Liyuan, Liu, Dejun, Lv, Yuan, Cui, Lanqing, Li, Yun, Li, Tianmeng, Song, Huangwei, Hao, Yuxin, Shen, Jianzhong, Wang, Yang and Walsh, Timothy R. ORCID: https://orcid.org/0000-0003-4315-4096 2019. Novel plasmid-mediated tet(X5) gene conferring resistance to tigecycline, eravacycline, and omadacycline in a clinical Acinetobacter baumannii Isolate. Antimicrobial Agents and Chemotherapy 64 (1) , e01326-19. 10.1128/AAC.01326-19

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Abstract

A novel, plasmid-mediated, high-level tigecycline resistance tet(X) gene variant, tet(X5), was detected in a clinical Acinetobacter baumannii isolate from China in 2017. Tet(X5) shows 84.5% and 90.5% amino acid identity to Tet(X3) and Tet(X4), respectively, with similar binding sites and a comparable affinity for tetracyclines. The tet(X5)-containing plasmid could only be transferred to A. baumannii via electrotransformation. This report follows the recent study describing the identification of tet(X3) and tet(X4).

Item Type:	Article
Date Type:	Published Online
Status:	Published
Schools:	Medicine
Publisher:	American Society for Microbiology
ISSN:	0066-4804
Date of Acceptance:	24 September 2019
Last Modified:	07 Nov 2022 10:04
URI:	https://orca.cardiff.ac.uk/id/eprint/131027

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