Minimal hippocampal width relates to plasma homocysteine in community-dwelling older people

Williams, Jonathan H., Pereira, Erlick A. C., Budge, Marc C. and Bradley, Kevin M. ORCID: https://orcid.org/0000-0003-1911-3382 2002. Minimal hippocampal width relates to plasma homocysteine in community-dwelling older people. Age and Ageing 31 (6) , pp. 440-444. 10.1093/ageing/31.6.440

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Abstract

Background: the hippocampus is important for memory. Hippocampal atrophy and higher levels of homocysteine may both predict cognitive dysfunction in community‐dwelling older people. We tested if higher homocysteine relates to hippocampal thinning in this group. Subjects: 156 community‐dwelling volunteers without clinical memory problems. Method: we measured minimal hippocampal widths on magnetic resonance images and homocysteine in plasma. Results: minimal hippocampal widths related inversely to homocysteine levels. Conclusions: our results indicate that, even in healthy older people, homocysteine may damage the hippocampus. Reducing homocysteine levels in healthy older people may help to prevent Alzheimer's disease.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Publisher:	Oxford University Press (OUP)
ISSN:	0002-0729
Date of Acceptance:	10 June 2002
Last Modified:	07 Nov 2022 10:22
URI:	https://orca.cardiff.ac.uk/id/eprint/132053

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