Randomised controlled trial of multi-modular motion-assisted memory desensitization and reconsolidation (3MDR) for male military veterans with treatment-resistant post-traumatic stress disorder

Bisson, J. I. ORCID: https://orcid.org/0000-0001-5170-1243, van Deursen, R. ORCID: https://orcid.org/0000-0002-9461-0111, Hannigan, B. ORCID: https://orcid.org/0000-0002-2512-6721, Kitchiner, N. ORCID: https://orcid.org/0000-0003-0499-9520, Barawi, K., Jones, K., Pickles, T. ORCID: https://orcid.org/0000-0001-7743-0234, Skipper, J., Young, C., Abbott, L. R., van Gelderen, M., Nijdam, M. J. and Vermetten, E. 2020. Randomised controlled trial of multi-modular motion-assisted memory desensitization and reconsolidation (3MDR) for male military veterans with treatment-resistant post-traumatic stress disorder. Acta Psychiatrica Scandinavica 142 (2) , pp. 141-151. 10.1111/acps.13200

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Abstract

Objective To explore the potential efficacy of multi‐modular motion‐assisted memory desensitisation and reprocessing (3MDR) in British military veterans with treatment‐resistant, service‐related PTSD. Methods Exploratory single‐blind, randomised, parallel arm, cross‐over controlled trial with nested process evaluation to assess fidelity, adherence and factors that influence outcome. Results 42 participants (all male) were randomised with 83% retention at 12 weeks and 86% at 26 weeks. The difference in mean Clinician Administered PTSD Scale for DSM‐5 scores between the immediate and delayed 3MDR arms was ‐9.38 (95% CI ‐17.33 to ‐1.44, p = 0.021) at 12 weeks and ‐3.59 (‐14.39 to 7.20, p= 0.513) at 26 weeks when both groups had received 3MDR. The likely effect size of 3MDR was found to be 0.65. Improvements were maintained at 26 week follow‐up. 3MDR was found to be acceptable to most, but not all, participants. Several factors that may impact efficacy and acceptability of 3MDR were identified. Conclusion 3MDR is a promising new intervention for treatment‐resistant PTSD with emerging evidence of effect.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Healthcare Sciences Medicine
Additional Information:	This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License
Publisher:	Wiley
ISSN:	0001-690X
Date of First Compliant Deposit:	4 June 2020
Date of Acceptance:	28 May 2020
Last Modified:	13 Dec 2024 13:40
URI:	https://orca.cardiff.ac.uk/id/eprint/132173

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