Clinical utilization of bacteriophages: a new perspective to combat the antimicrobial resistance in Brazil

Martins, Willames M. B. S., Toleman, Mark A. ORCID: https://orcid.org/0000-0002-9497-0512 and Gales, Ana C. 2020. Clinical utilization of bacteriophages: a new perspective to combat the antimicrobial resistance in Brazil. Brazilian Journal of Infectious Diseases 24 (3) , pp. 239-246. 10.1016/j.bjid.2020.04.010

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Abstract

Due to the emergence of multi-drug resistant bacteria, and the evident limitation in therapeutic options, alternatives to combat bacterial infections have been sought. One of these is phage therapy, which is the use of bacterial viruses to kill pathogenic bacteria responsible for the infection. These viruses called bacteriophages are very abundant organisms in the world and are harmless to humans. There are several advantages in using phage therapy, especially against multi-drug resistant pathogens, which tend to be dominated by individual strains. The advantages include fewer collateral effects such as lower disturbance of gut microbiota and less antimicrobials consumption, which itself leads to reducing antibiotic resistance rates. Unfortunately, few clinical studies have been initiated in Brazil and this area is little explored in our country. This manuscript describes clinical evidence of successful phage utilization on pathogens considered a threat in Brazil, highlighting the benefits of a possible phage utilization as an important tool to combat antimicrobial resistance in our country.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Schools > Medicine
Publisher:	Elsevier / Brazilian Society of Infectious Diseases
ISSN:	1413-8670
Date of First Compliant Deposit:	10 June 2020
Date of Acceptance:	11 April 2020
Last Modified:	12 May 2023 13:16
URI:	https://orca.cardiff.ac.uk/id/eprint/132311

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