Wright, Rachel, Oremek, Maximilian, Davies, David, Kewley, Caitlin, Singh, Alyssa, Taitt, Nathaniel, Kempshall, Emma, Wilson, Keith and Ingram, Wendy 2020. Quality of life following allogeneic stem cell transplantation for patients age >60 years with acute myelogenous leukemia. Biology of Blood and Marrow Transplantation 26 (8) , pp. 1527-1533. 10.1016/j.bbmt.2020.04.020 |
Abstract
This study of patients with acute myelogenous leukemia (AML) age60 years analyzed the association betweenpatients’performance indices—Hematopoietic Stem Cell Transplantation Comorbidity Index (HCT-CI), KarnofskyPerformance Score (KPS), and European Society for Blood and Marrow Transplantation (EBMT) risk score—beforeundergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT) and quality of life (QoL), quantifiedusing the Functional Assessment of Cancer Therapy-Bone Marrow Transplant Scale (FACT-BMT), in thefirst yearafter allo-HSCT. Over a period of 7 years, 48 evaluable patients underwent reduced-intensity conditioning allo-HSCT. The median patient age was 65 years (range, 60 to 74 years), with 2-year and 5-year overall survival (OS) of65.8% and 52.3%, respectively. A significant improvement across all QoL scores was observed over the 12 monthspost-HSCT. An HCT-CI of 0 was associated with improved general QoL (FACT-G) score at 6 months compared withpatients with an HCT-CI of 1 to 2 (P= .032). At 12 months post-HSCT, a pretransplantation HCT-CI3 was corre-lated with lower QoL scores across the domains (symptom-related QoL [FACT-TOI],P= .036; FACT-G,P= .05; BMT-related QoL [FACT-BMT],P= .036). A pretransplantation KPS score of 100 versus 80 to 90 was predictive ofimproved QoL at 6 months post-HSCT (FACT-TOI,P= .009; FACT-G,P= .001; FACT-BMT,P= .002) but not at 1 yearpost-HSCT. We demonstrate that KPS and HCT-CI can predict QoL in the early post-transplantation period, with afavorable overall survival in a selected cohort of AML patients age60 years.
Item Type: | Article |
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Date Type: | Publication |
Status: | Published |
Schools: | Medicine |
Publisher: | Elsevier |
ISSN: | 1083-8791 |
Date of Acceptance: | 16 April 2020 |
Last Modified: | 06 May 2023 02:11 |
URI: | https://orca.cardiff.ac.uk/id/eprint/132924 |
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