Quetiapine regulates FGF-2 and BDNF expression in the hippocampus of animals treated with MK-801.

Fumagalli, Fabio, Raffaella, Molteni, Bedogni, Francesco, Massimo, Gennarelli, Perez, Jorge, Racagni, Giogio and Riva, Marco A. 2004. Quetiapine regulates FGF-2 and BDNF expression in the hippocampus of animals treated with MK-801. NeuroReport 15 (13) , pp. 2109-2112. 10.1097/00001756-200409150-00022

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Abstract

Fibroblast growth factor-2 (FGF-2) and brain-derived neurotrophic factor (BDNF) are trophic factors, widely distributed in the adult brain, whose expression can be modulated by psychoactive drugs. Administration of the atypical antipsychotic quetiapine resulted in a marked elevation of FGF-2 and BDNF mRNA levels in the rat hippocampus, but only under conditions of reduced NMDA receptor activity. These effects were drug-specific, given that they were not observed with the conventional antipsychotic haloperidol; and anatomically defined, since no similar effect was observed in striatum, prefrontal or frontal cortex. These results suggest that quetiapine may promote neuroplasticity via the up-regulation of neurotrophic factors when NMDA-mediated transmission is perturbed.

Item Type:	Article
Date Type:	Published Online
Status:	Published
Schools:	Biosciences
Publisher:	Lippincott, Williams & Wilkins
ISSN:	0959-4965
Last Modified:	06 Jul 2020 12:15
URI:	https://orca.cardiff.ac.uk/id/eprint/133008

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