Association between neonatal resuscitation and a single nucleotide polymorphism rs1835740

Odd, David ORCID: https://orcid.org/0000-0002-6416-4966, Váradi, Anikó, Rajatileka, Shavanthi, Molnár, Elek and Luyt, Karen 2016. Association between neonatal resuscitation and a single nucleotide polymorphism rs1835740. Acta Pædiatrica 105 (7) , e307-e312. 10.1111/apa.13421

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Abstract

Aim The aim of this work was to test whether three single nucleotide polymorphisms (SNP s) implicated in glutamate homoeostasis or signalling and cellular survival are associated with birth condition. Methods This study is drawn from the Avon Longitudinal Study of Parents and Children. A total of 7611 term infants were genotyped and patient outcome data retrieved from routine medical records. Exposure measures were the presence of one or more minor alleles in one of 3 SNP s (rs2284411, rs2498804, rs1835740). The primary outcome was the need for resuscitation at birth. Results For SNP rs1835740, infants homozygous for the minor allele compared to wild type were more likely to need resuscitation (9.2% vs. 7.0%, p = 0.041), while the odds ratio for resuscitation was associated with each increasing minor allele [OR 1.17 (1.01–1.35)]. Population attributable risk fraction was 6.5%. There was no evidence that the other two SNP s investigated were associated with birth condition. Conclusion We have tested three candidate SNP s to measure any association with birth condition. The study revealed that the rs1835740 was associated with the need for resuscitation and Apgar scores, with a substantial population impact.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Publisher:	Wiley
ISSN:	0803-5253
Date of Acceptance:	4 April 2016
Last Modified:	07 Nov 2022 10:43
URI:	https://orca.cardiff.ac.uk/id/eprint/133348

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