Self-assembly to function: design, synthesis, and broad spectrum antimicrobial properties of short hybrid E-vinylogous lipopeptides

Shankar, S. Shiva, Benke, Sushil N., Nagendra, Narem, Srivastava, Prabhakar Lal ORCID: https://orcid.org/0000-0002-8219-6419, Thulasiram, Hirekodathakallu V. and Gopi, Hosahudya N. 2013. Self-assembly to function: design, synthesis, and broad spectrum antimicrobial properties of short hybrid E-vinylogous lipopeptides. Journal of Medicinal Chemistry 56 (21) , pp. 8468-8474. 10.1021/jm400884w

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Abstract

Nonribosomal E-vinylogous γ-amino acids are widely present in many peptide natural products and have been exploited as inhibitors for serine and cysteine proteases. Here, we are reporting the broad spectrum antimicrobial properties and self-assembled nanostructures of various hybrid lipopeptides composed of 1:1 alternating α- and E-vinylogous residues. Analysis of the results revealed that self-assembled nanostructures also play a significant role in the antimicrobial and hemolytic activities. In contrast to the α-peptide counterparts, vinylogous hybrid peptides displayed excellent antimicrobial properties against various bacterial and fungal strains. Peptides that adopted nanofiber structures displayed less hemolytic activity, while peptides that adopted nanoneedle structures displayed the highest hemolytic activity.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Chemistry
Publisher:	American Chemical Society
ISSN:	0022-2623
Last Modified:	16 Jan 2024 02:21
URI:	https://orca.cardiff.ac.uk/id/eprint/133381

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