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Generating excitotoxic lesion models of Huntington’s Disease

Lelos, Mariah J. ORCID: and Dunnett, Stephen B. 2018. Generating excitotoxic lesion models of Huntington’s Disease. Precious, Sophie V., Rosser, Anne E. and Dunnett, Stephen B., eds. Huntington’s Disease, Methods in Molecular Biology, New York, NY, USA: pp. 209-220. (10.1007/978-1-4939-7825-0_11)

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In Huntington’s disease (HD), the medium spiny projection neurons of the neostriatum degenerate early in the course of the disease. While genetic mutant models of HD provide an excellent resource for studying the molecular and cellular effects of the inherited polyQ huntingtin mutation, they do not typically present with overt atrophy of the basal ganglia, despite this being a major pathophysiological hallmark of the disease. By contrast, excitotoxic lesion models, which use quinolinic acid to specifically target the striatal projection neurons, are employed to study the functional consequences of striatal atrophy and to investigate potential therapeutic interventions that target the neuronal degeneration. This chapter provides a detailed guide to the generation of excitotoxic lesion models of HD in rats.

Item Type: Book Section
Date Type: Published Online
Status: Published
Schools: Biosciences
ISBN: 9781493978243
Last Modified: 07 Nov 2022 10:51

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