Prospective observational data informs understanding and future management of Lynch syndrome: insights from the Prospective Lynch Syndrome Database (PLSD)

Seppälä, Toni T., Dominguez-Valentin, Mev, Sampson, Julian R. ORCID: https://orcid.org/0000-0002-2902-2348 and Møller, Pål 2021. Prospective observational data informs understanding and future management of Lynch syndrome: insights from the Prospective Lynch Syndrome Database (PLSD). Familial Cancer 20 , pp. 35-39. 10.1007/s10689-020-00193-2

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Abstract

The Prospective Lynch Syndrome Database (PLSD) has been developed as an international, multicentre, prospective, observational study that aims to provide age and organ-specific cancer risks according to gene and gender, estimates of survival after cancer and information on the effects of interventions. Recent reports from PLSD provided improved estimates of cancer risks and survival and showed that different time intervals between surveillance colonoscopies did not affect the incidence, stage or prognosis of colorectal cancer. The PLSD reports suggest that current management guidelines for Lynch syndrome should be revised in light of the different gene and gender-specific cancer risks and the good prognosis for the most commonly associated cancers. In this review, we describe the discrepancies between the current management guidelines for Lynch Syndrome and the most recent prospective observational studies, indicating the areas of further research. Keywords Lynch syndrome · Hereditary non-polyposis colorectal cancer · Colorectal cancer · Colonoscopy · Surveillance · Prevention · Precision medicine · PLSD · Cancer incidence

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Additional Information:	This article is licensed under a Creative Commons Attribution 4.0 International License
Publisher:	Springer Verlag (Germany)
ISSN:	1389-9600
Date of First Compliant Deposit:	3 August 2020
Date of Acceptance:	2 June 2020
Last Modified:	07 Nov 2022 10:55
URI:	https://orca.cardiff.ac.uk/id/eprint/133935

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