Demographic and socioeconomic patterns in the risk of alcohol-related hospital admission in children and young adults with childhood onset type-1 diabetes from a record-linked longitudinal population cohort study in Wales

Gartner, Andrea ORCID: https://orcid.org/0000-0002-0369-4402, Daniel, Rhian ORCID: https://orcid.org/0000-0001-5649-9320, Farewell, Daniel ORCID: https://orcid.org/0000-0002-8871-1653, Paranjothy, Shantini ORCID: https://orcid.org/0000-0002-0528-3121, Townson, Julia ORCID: https://orcid.org/0000-0001-8679-3619 and Gregory, John W ORCID: https://orcid.org/0000-0001-5189-3812 2020. Demographic and socioeconomic patterns in the risk of alcohol-related hospital admission in children and young adults with childhood onset type-1 diabetes from a record-linked longitudinal population cohort study in Wales. Pediatric Diabetes 21 (7) , pp. 1333-1342. 10.1111/pedi.13089

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Abstract

Background Little is known about alcohol-related harm in children and young adults with type 1 diabetes (T1D). Education on managing alcohol intake is provided to teenagers with T1D in paediatric clinics in Wales, but its effectiveness is unknown. We compared the patterns in risk of alcohol-related hospital admissions (ARHA) between individuals with and without childhood-onset T1D. Methods We extracted data for 1,791,577 individuals born during 1979-2014 with a GP registration in Wales, and record-linked the demographic data to ARHA between 1998 and June 2016 within the Secure Anonymised Information Linkage Databank (SAIL). Linkage to a national T1D register (Brecon Cohort) identified 3,575 children diagnosed aged <15 years since 1995. We estimated hazard ratios (HRs) with 95% confidence intervals (95% CIs) for the risk of ARHA using recurrent-event models, including interaction terms. Results Individuals with T1D had a higher risk of ARHA (HR: 1.78; 95% CI: 1.60-1.98), adjusted for age group, sex and deprivation. The risk in people with diabetes was highest aged 14-17 years, around three times higher than the peak in non-T1D aged 18-22. Females with diabetes had a lower risk generally. The association between deprivation and ARHA was weaker in the T1D group. Conclusion Young people with T1D had increased risks of ARHA, particularly at school age, and smaller socioeconomic inequalities in ARHA. A review of interventions to reduce alcohol-related harm in T1D is needed, perhaps including modification of current education and guidance for teenagers on managing alcohol consumption and reviewing criteria for hospital admission.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine Centre for Trials Research (CNTRR)
Publisher:	Wiley
ISSN:	1399-543X
Date of First Compliant Deposit:	10 August 2020
Date of Acceptance:	27 July 2020
Last Modified:	05 May 2023 13:29
URI:	https://orca.cardiff.ac.uk/id/eprint/134038

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