Antibodies to glutamate facilitate spatial memory formation in the Morris maze in aging C57BL/6 mice

Davydova, T. V., Gruden, M. A., Kudrin, V. S., Narkevich, V. B., Vetrile, L.A., Zakharova, I. A. and Sewell, R. D. E. 2020. Antibodies to glutamate facilitate spatial memory formation in the Morris maze in aging C57BL/6 mice. Bulletin of Experimental Biology and Medicine 169 (1) , pp. 5-8. 10.1007/s10517-020-04812-x

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Abstract

Intranasal administration of antibodies to glutamate at dose of 250 μg/kg for two weeks facilitated spatial learning and memory formation in the Morris water maze in aging C57Bl/6 mice. Concurrently, in the animals treated with glutamate antibodies, there was a decrease in serotonin level, no change in dopamine but a reduction in 3-MT and HVA metabolite concentrations in the hippocampus. In the prefrontal cortex, a decrease in dopamine level occurred along with a simultaneous increase in the content of its metabolite, DOPAC, as well as an increase in excitatory and inhibitory amino acid neurotransmitters: aspartic acid, glutamate, glycine, taurine and GABA. It was concluded that Abs-Glu facilitated spatial learning and memory formation through a remodeling of the hippocampal and prefrontal cortical neurochemical system in aging C57Bl/6 mice.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Pharmacy
Subjects:	R Medicine > RM Therapeutics. Pharmacology
Uncontrolled Keywords:	aging, memory, antibodies to glutamate, neurotransmitters
Publisher:	Springer Verlag (Germany)
ISSN:	0007-4888
Date of First Compliant Deposit:	17 August 2020
Date of Acceptance:	11 July 2019
Last Modified:	23 Nov 2024 14:00
URI:	https://orca.cardiff.ac.uk/id/eprint/134220

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