Mechanisms underpinning the efficacy of faecal microbiota transplantation in treating gastrointestinal disease

Segal, Jonathan P., Mullish, Benjamin H., Quraishi, Mohammed N., Iqbal, Tariq, Marchesi, Julian R. ORCID: https://orcid.org/0000-0002-7994-5239 and Sokol, Harry 2020. Mechanisms underpinning the efficacy of faecal microbiota transplantation in treating gastrointestinal disease. Therapeutic Advances in Gastroenterology 13 , pp. 1-14. 10.1177/1756284820946904

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Abstract

Faecal microbiota transplantation (FMT) is currently a recommended therapy for recurrent/refractory Clostridioides difficile infection (CDI). The success of FMT for CDI has led to interest in its therapeutic potential in many other disorders. The mechanisms that underpin the efficacy of FMT are not fully understood. Importantly, FMT remains a crucial treatment in managing CDI and understanding the mechanisms that underpin its success will be critical to improve its clinical efficacy, safety and usability. Furthermore, a deeper understanding of this may allow us to expose FMT’s full potential as a therapeutic tool for other disease states. This review will explore the current understanding of the mechanisms underlying the efficacy of FMT across a variety of diseases.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences
Publisher:	SAGE
ISSN:	1756-283X
Date of First Compliant Deposit:	22 September 2020
Date of Acceptance:	13 July 2020
Last Modified:	04 May 2023 19:50
URI:	https://orca.cardiff.ac.uk/id/eprint/135019

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