Hatcher, Lauren E.  ORCID: https://orcid.org/0000-0002-1549-9727, Burgess, Ayrton J., Payne, Pollyanna and Wilson, Chick C
2020.
From structure to crystallisation and pharmaceutical manufacturing: the CSD in CMAC Workflows.
CrystEngComm
22
, pp. 7475-7489.
10.1039/D0CE00898B
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Abstract
Two Workflows are presented that are relevant to the design and construction of end-to-end pharmaceutiucal manufacturing processes. The Workflows target the very early stage crystallisation aspect of these processes – production of the primary crystalline solid form – and relate to establishing decision-driven approaches for the screening for multi-component forms, specifically co-crystals, and to the use of additives to control crystal and primary particle form, notably morphology. These Workflows are shown to benefit from the use of the Million-plus structures in the Cambridge Structural Database and the associated structural informatics and analysis tools and are placed into the context of the work of the CMAC Future Manufacturing Hub.
| Item Type: | Article |
|---|---|
| Date Type: | Publication |
| Status: | Published |
| Schools: | Schools > Chemistry |
| Publisher: | Royal Society of Chemistry |
| ISSN: | 1466-8033 |
| Date of First Compliant Deposit: | 23 September 2020 |
| Date of Acceptance: | 15 September 2020 |
| Last Modified: | 04 May 2023 13:13 |
| URI: | https://orca.cardiff.ac.uk/id/eprint/135035 |
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