Potential therapeutic benefit of NAD+ supplementation for glaucoma and age-related macular degeneration

Cimaglia, Gloria, Votruba, Marcela ORCID: https://orcid.org/0000-0002-7680-9135, Morgan, James E. ORCID: https://orcid.org/0000-0002-8920-1065, André, Helder and Williams, Pete A. 2020. Potential therapeutic benefit of NAD+ supplementation for glaucoma and age-related macular degeneration. Nutrients 12 (9) , 2871. 10.3390/nu12092871

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Abstract

Glaucoma and age-related macular degeneration are leading causes of irreversible blindness worldwide with significant health and societal burdens. To date, no clinical cures are available and treatments target only the manageable symptoms and risk factors (but do not remediate the underlying pathology of the disease). Both diseases are neurodegenerative in their pathology of the retina and as such many of the events that trigger cell dysfunction, degeneration, and eventual loss are due to mitochondrial dysfunction, inflammation, and oxidative stress. Here, we critically review how a decreased bioavailability of nicotinamide adenine dinucleotide (NAD; a crucial metabolite in healthy and disease states) may underpin many of these aberrant mechanisms. We propose how exogenous sources of NAD may become a therapeutic standard for the treatment of these conditions. View Full-Text Keywords: nicotinamide adenine dinucleotide; glaucoma; age-related macular degeneration; mitochondria; retina; optic nerve; retinal pigment epithelium

Item Type:	Article
Date Type:	Published Online
Status:	Published
Schools:	Optometry and Vision Sciences Medicine
Publisher:	MDPI
ISSN:	2072-6643
Funders:	Fight for Sight
Date of First Compliant Deposit:	5 October 2020
Date of Acceptance:	17 September 2020
Last Modified:	05 May 2023 06:34
URI:	https://orca.cardiff.ac.uk/id/eprint/135263

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