Diffusion-weighted MRI in neurodegenerative and psychiatric animal models: experimental strategies and main outcomes

Eed, Amr, Cerdá, Antonio Cerdán, Lerma, Juan and De Santis, Silvia ORCID: https://orcid.org/0000-0001-9739-6926 2020. Diffusion-weighted MRI in neurodegenerative and psychiatric animal models: experimental strategies and main outcomes. Journal of Neuroscience Methods 343 , 108814. 10.1016/j.jneumeth.2020.108814

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Abstract

Preclinical MRI approaches constitute a key tool to study a wide variety of neurological and psychiatric illnesses, allowing a more direct investigation of the disorder substrate and, at the same time, the possibility of back-translating such findings to human subjects. However, the lack of consensus on the optimal experimental scheme used to acquire the data has led to relatively high heterogeneity in the choice of protocols, which can potentially impact the comparison between results obtained by different groups, even using the same animal model. This is especially true for diffusion-weighted MRI data, where certain experimental choices can impact not only on the accuracy and precision of the extracted biomarkers, but also on their biological meaning. With this in mind, we extensively examined preclinical imaging studies that used diffusion-weighted MRI to investigate neurodegenerative, neurodevelopmental and psychiatric disorders in rodent models. In this review, we discuss the main findings for each preclinical model, with a special focus on the analysis and comparison of the different acquisition strategies used across studies and their impact on the heterogeneity of the findings.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Psychology Cardiff University Brain Research Imaging Centre (CUBRIC)
Publisher:	Elsevier
ISSN:	0165-0270
Date of First Compliant Deposit:	16 October 2020
Date of Acceptance:	16 June 2020
Last Modified:	26 Nov 2024 14:15
URI:	https://orca.cardiff.ac.uk/id/eprint/135673

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