Genome analysis of the platypus reveals unique signatures of evolution

Warren, Wesley C., Hillier, LaDeana W., Marshall Graves, Jennifer A., Birney, Ewan, Ponting, Chris P., Grützner, Frank, Belov, Katherine, Miller, Webb, Clarke, Laura, Chinwalla, Asif T., Yang, Shiaw-Pyng, Heger, Andreas, Locke, Devin P., Miethke, Pat, Waters, Paul D., Veyrunes, Frédéric, Fulton, Lucinda, Fulton, Bob, Graves, Tina, Wallis, John, Puente, Xose S., López-Otín, Carlos, Ordóñez, Gonzalo R., Eichler, Evan E., Chen, Lin, Cheng, Ze, Deakin, Jenine E., Aslop, Amber, Thompson, Katherine, Kirby, Patrick, Papenfuss, Anthony T., Wakefield, Matthew J., Olender, Tsviya, Lancet, Doron, Huttley, Gavin A., Smit, Arian F. A., Pask, Andrew, Temple-Smith, Peter, Batzer, Mark A., Walker, Jerilyn A., Konkel, Miriam K., Harris, Robert S., Whittington, Camilla M., Wong, Emily S. W., Gemmell, Neil J., Buschiazzo, Emmanuel, Vargas Jentzsch, Iris M., Merkel, Angelika, Schmitz, Juergen, Zemann, Anja, Churakov, Gennady, Kriegs, Jan Ole, Brosius, Juergen, Murchison, Elizabeth P., Sachidanandam, Ravi, Smith, Carly, Hannon, Gregory J., Tsend-Ayush, Enkhjargal, McMillan, Daniel, Attenborough, Rosalind, Rens, Willem, Ferguson-Smith, Malcolm, Lefèvre, Christophe M., Sharp, Julie A., Nicholas, Kevin R., Ray, David A., Kube, Michael, Reinhardt, Richard, Pringle, Thomas H., Taylor, James, Jones, Russell C., Nixon, Brett, Dacheux, Jean-Louis, Niwa, Hitoshi, Sekita, Yoko, Huang, Xiaoqiu, Stark, Alexander, Kheradpour, Pouya, Kellis, Manolis, Flicek, Paul, Chen, Yuan, Webber, Caleb ORCID: https://orcid.org/0000-0001-8063-7674, Hardison, Ross, Nelson, Joanne, Hallsworth-Pepin, Kym, Delehaunty, Kim, Markovic, Chris, Minx, Pat, Feng, Yucheng, Kremitzki, Colin, Mitreva, Makedonka, Glasscock, Jarret, Wylie, Todd, Wohldmann, Patricia, Thiru, Prathapan, Nhan, Michael N., Pohl, Craig S., Smith, Scott M., Hour, Shungfeng, renfree, Marilyn B., Mardis, Elaine R. and Wilson, Richard K. 2008. Genome analysis of the platypus reveals unique signatures of evolution. Nature 453 , pp. 175-183. 10.1038/nature06936

PDF - Published Version Available under License Creative Commons Attribution Non-commercial Share Alike. Download (506kB)

Abstract

We present a draft genome sequence of the platypus, Ornithorhynchus anatinus. This monotreme exhibits a fascinating combination of reptilian and mammalian characters. For example, platypuses have a coat of fur adapted to an aquatic lifestyle; platypus females lactate, yet lay eggs; and males are equipped with venom similar to that of reptiles. Analysis of the first monotreme genome aligned these features with genetic innovations. We find that reptile and platypus venom proteins have been co-opted independently from the same gene families; milk protein genes are conserved despite platypuses laying eggs; and immune gene family expansions are directly related to platypus biology. Expansions of protein, non-protein-coding RNA and microRNA families, as well as repeat elements, are identified. Sequencing of this genome now provides a valuable resource for deep mammalian comparative analyses, as well as for monotreme biology and conservation.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Additional Information:	Erratum published at http://doi.org/10.1038/nature07253 and noted at the end of the PDF file for this article.
Publisher:	Nature Research
ISSN:	0028-0836
Date of First Compliant Deposit:	23 October 2020
Date of Acceptance:	25 March 2008
Last Modified:	07 May 2023 19:36
URI:	https://orca.cardiff.ac.uk/id/eprint/135807

Citation Data

Cited 538 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item