Discordant binocular or mixed monocular-binocular vision reliability of cortical responses to binocular disparity stimuli dependent on the order of presentation

Vorobyov, Vasily, Schwarzkopf, D. S., Mitchell, D. E. and Sengpiel, Frank ORCID: https://orcid.org/0000-0002-7060-1851 2008. Discordant binocular or mixed monocular-binocular vision reliability of cortical responses to binocular disparity stimuli dependent on the order of presentation. FENS Abstracts 4 , 054.45.

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Abstract

Brief daily binocular vision has been shown to outweigh detrimental effects of much longer monocular deprivation (Mitchell et al., 2006, Schwarzkopf et al., 2007). In order to analyse binocular mechanisms associated with this phenomenon, we studied neuronal responses in primary visual cortex to binocular spatial phase disparity stimuli in cats that had experienced discordant binocular vision (through optically or surgically induced strabismus or a daily mix of binocular and monocular visual exposure. We examined binocular responses in two consecutive trials to disparity stimuli, with different relative phases being shown either in random order or sequentially (increasing or decreasing disparities). The percentage of phase-selective cells was reduced in animals with abnormal visual experience independent of stimulus order. In a subpopulation of "unstable" phase-selective cells, the strongest and weakest responses in two trials were elicited at different relative phases elicited (while having similar peak-to-peak amplitude ratios). With randomized presentation, the percentage of unstable cells increased with decreasing proportion of daily binocular exposure. Sequential stimulation increased the proportion of "unstable" phase-selective cells in strabismic cats and in those with brief (0.5 h) daily binocular and much longer (6.5 h) monocular experience. We suggest that the detrimental effect of discordant binocular or mixed monocular and binocular visual exposure on binocular processing in visual cortex may be associated with a subtle disruption of the mechanism(s) involved in discrimination of binocular disparity signals and in evaluation of their temporal evolution.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences Neuroscience and Mental Health Research Institute (NMHRI)
Publisher:	Federation of European Neuroscience Societies (FENS)
ISSN:	1749-6187
Related URLs:	Publisher
Last Modified:	18 Oct 2022 13:22
URI:	https://orca.cardiff.ac.uk/id/eprint/13618

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