Prostate cancer undetected by mpMRI: tumor conspicuity is reliant upon optimal scan timing and quality

Norris, Joseph M., Allen, Clare, Ball, Rhys, Freeman, Alex, Giganti, Francesco, Kelly, Daniel ORCID: https://orcid.org/0000-0002-1847-0655, Kirkham, Alex, Simpson, Benjamin S., Stavrinides, Vasilis, Whitaker, Hayley C. and Emberton, Mark 2021. Prostate cancer undetected by mpMRI: tumor conspicuity is reliant upon optimal scan timing and quality. Urology 148 , pp. 316-317. 10.1016/j.urology.2020.11.037

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Abstract

We commend Alanee et al for their detailed description of prostate cancers not detected by multiparametric magnetic resonance imaging (mpMRI). 1 They analyzed radical prostatectomy findings for 33 men lacking mpMRI-conspicuous prostate cancer (defined as Prostate Imaging Reporting and Data System [PI-RADS] scores 1-2) on preoperative mpMRI. They found 27% (9/33) of men with negative mpMRI had Gleason Grade Group (GGG) 3-5 cancer at prostatectomy, including 9 with extraprostatic extension, and 1 with Gleason grade 5 + 5 disease. Ostensibly, these findings are at odds with contemporary evidence in which mpMRI-invisible disease harbors reassuring molecular and histopathological features (ie, overall GGG ≤2). 2 , 3 We believe that this discrepancy is attributable to certain methodological concerns, including quality of mpMRI acquisiton. 4

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Healthcare Sciences
Publisher:	Elsevier
ISSN:	0090-4295
Date of First Compliant Deposit:	31 March 2021
Last Modified:	04 Dec 2024 22:45
URI:	https://orca.cardiff.ac.uk/id/eprint/136839

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