Prime-boost vaccination with chimpanzee adenovirus and modified vaccinia Ankara encoding TRAP provides partial protection againstPlasmodium falciparuminfection in Kenyan adults

Ogwang, Caroline, Kimani, Domtila, Edwards, Nick J., Roberts, Rachel, Mwacharo, Jedidah, Bowyer, Georgina, Bliss, Carly, Hodgson, Susanne H., Njuguna, Patricia, Viebig, Nicola K., Nicosia, Alfredo, Gitau, Evelyn, Douglas, Sandy, Illingworth, Joe, Marsh, Kevin, Lawrie, Alison, Imoukhuede, Egeruan B., Ewer, Katie, Urban, Britta C., S. Hill, Adrian V. and Bejon, Philip 2015. Prime-boost vaccination with chimpanzee adenovirus and modified vaccinia Ankara encoding TRAP provides partial protection againstPlasmodium falciparuminfection in Kenyan adults. Science Translational Medicine 7 (286) , 286re5. 10.1126/scitranslmed.aaa2373

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Abstract

Protective immunity to the liver stage of the malaria parasite can be conferred by vaccine-induced T cells, but no subunit vaccination approach based on cellular immunity has shown efficacy in field studies. We randomly allocated 121 healthy adult male volunteers in Kilifi, Kenya, to vaccination with the recombinant viral vectors chimpanzee adenovirus 63 (ChAd63) and modified vaccinia Ankara (MVA), both encoding the malaria peptide sequence ME-TRAP (the multiple epitope string and thrombospondin-related adhesion protein), or to vaccination with rabies vaccine as a control. We gave antimalarials to clear parasitemia and conducted PCR (polymerase chain reaction) analysis on blood samples three times a week to identify infection with the malaria parasite Plasmodium falciparum. On Cox regression, vaccination reduced the risk of infection by 67% [95% confidence interval (CI), 33 to 83%; P = 0.002] during 8 weeks of monitoring. T cell responses to TRAP peptides 21 to 30 were significantly associated with protection (hazard ratio, 0.24; 95% CI, 0.08 to 0.75; P = 0.016).

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Publisher:	American Association for the Advancement of Science
ISSN:	1946-6234
Date of Acceptance:	23 April 2015
Last Modified:	06 Jan 2021 12:45
URI:	https://orca.cardiff.ac.uk/id/eprint/137199

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