Apparent propagator anisotropy from single-shell diffusion MRI acquisitions

Aja-Fernández, Santiago, Tristán-Vega, Antonio and Jones, Derek K. ORCID: https://orcid.org/0000-0003-4409-8049 2021. Apparent propagator anisotropy from single-shell diffusion MRI acquisitions. Magnetic Resonance in Medicine 85 (5) , pp. 2869-2881. 10.1002/mrm.28620

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Abstract

Purpose The apparent propagator anisotropy (APA) is a new diffusion MRI metric that, while drawing on the benefits of the ensemble averaged propagator anisotropy (PA) compared to the fractional anisotropy (FA), can be estimated from single‐shell data. Theory and Methods Computation of the full PA requires acquisition of large datasets with many diffusion directions and different b‐values, and results in extremely long processing times. This has hindered adoption of the PA by the community, despite evidence that it provides meaningful information beyond the FA. Calculation of the complete propagator can be avoided under the hypothesis that a similar sensitivity/specificity may be achieved from apparent measurements at a given shell. Assuming that diffusion anisotropy (DiA) is nondependent on the b‐value, a closed‐form expression using information from one single shell (ie, b‐value) is reported. Results Publicly available databases with healthy and diseased subjects are used to compare the APA against other anisotropy measures. The structural information provided by the APA correlates with that provided by the PA for healthy subjects, while it also reveals statistically relevant differences in white matter regions for two pathologies, with a higher reliability than the FA. Additionally, APA has a computational complexity similar to the FA, with processing‐times several orders of magnitude below the PA. Conclusions The APA can extract more relevant white matter information than the FA, without any additional demands on data acquisition. This makes APA an attractive option for adoption into existing diffusion MRI analysis pipelines.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Cardiff University Brain Research Imaging Centre (CUBRIC) Psychology
Additional Information:	This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Publisher:	Wiley
ISSN:	0740-3194
Funders:	Wellcome Trust
Date of First Compliant Deposit:	6 January 2021
Date of Acceptance:	6 November 2020
Last Modified:	03 May 2023 02:37
URI:	https://orca.cardiff.ac.uk/id/eprint/137352

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