Transcription factors in parathyroid development: lessons from hypoparathyroid disorders

Grigorieva, Irina V. and Thakker, Rajesh V. 2011. Transcription factors in parathyroid development: lessons from hypoparathyroid disorders. Annals of the New York Academy of Sciences 1237 (1) , pp. 24-38. 10.1111/j.1749-6632.2011.06221.x

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Abstract

Parathyroid developmental anomalies, which result in hypoparathyroidism, are common and may occur in one in 4,000 live births. Parathyroids, in man, develop from the endodermal cells of the third and fourth pharyngeal pouches, whereas, in the mouse they develop solely from the endoderm of the third pharyngeal pouches. In addition, neural crest cells that arise from the embryonic mid‐ and hindbrain also contribute to parathyroid gland development. The molecular signaling pathways that are involved in determining the differentiation of the pharyngeal pouch endoderm into parathyroid cells are being elucidated by studies of patients with hypoparathyroidism and appropriate mouse models. These studies have revealed important roles for a number of transcription factors, which include Tbx1, Gata3, Gcm2, Sox3, Aire1 and members of the homeobox (Hox) and paired box (Pax) families.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Publisher:	Wiley
ISSN:	0077-8923
Last Modified:	15 Jan 2021 15:00
URI:	https://orca.cardiff.ac.uk/id/eprint/137622

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