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X-linked imprinting: effects on brain and behaviour

Davies, William ORCID:, Isles, Anthony Roger ORCID:, Burgoyne, Paul S. and Wilkinson, Lawrence Stephen ORCID: 2006. X-linked imprinting: effects on brain and behaviour. Bioessays 28 (1) , pp. 35-44. 10.1002/bies.20341

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Imprinted genes are monoallelically expressed in a parent-of-origin-dependent manner and can affect brain and behavioural phenotypes. The X chromosome is enriched for genes affecting neurodevelopment and is donated asymmetrically to male and female progeny. Hence, X-linked imprinted genes could potentially influence sexually dimorphic neurobiology. Consequently, investigations into such loci may provide new insights into the biological basis of behavioural differences between the sexes and into why men and women show different vulnerabilities to certain mental disorders. In this review, we summarise recent advances in our knowledge of X-linked imprinted genes and the brain substrates that they may act upon. In addition, we suggest strategies for identifying novel X-linked imprinted genes and their downstream effects and discuss evolutionary theories regarding the origin and maintenance of X-linked imprinting.

Item Type: Article
Status: Published
Schools: Psychology
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Neuroscience and Mental Health Research Institute (NMHRI)
Publisher: Wiley-Blackwell
ISSN: 0265-9247
Last Modified: 28 Sep 2023 12:28

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