Decoding the auditory nerve to simulate sensorineural pathologies and help refine their diagnosis

Grange, Jacques ORCID: https://orcid.org/0000-0001-5197-249X and Culling, John ORCID: https://orcid.org/0000-0003-1107-9802 2021. Decoding the auditory nerve to simulate sensorineural pathologies and help refine their diagnosis. Presented at: Forum Acusticum 2020 (e-FA), Virtual (Lyon, France), 7-11 December 2020. Forum Acusticum. Forum Acusticum 2020 Proceedings. e-Forum Acusticum 2020, pp. 2999-3002. 10.48465/fa.2020.0522

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Abstract

Pathologies underlying sensorineural hearing loss (SNHL) cannot yet be differentially diagnosed. An advanced SNHL simulator takes the stimulus encoding by Meddis and colleagues’ Model of the Auditory Periphery [1] at the auditory nerve (AN) level and decodes it into a signal used in psychophysical tasks to determine the signatures of specific pathologies. Speech reception thresholds (SRTs) for stimuli processed through the normal-hearing (NH) simulator, were just 1 dB higher than those obtained for unprocessed stimuli. With both efferent reflexes disabled, SRTs grew by ~4 dB. Simulated rate-level functions illustrate how efferent reflexes enable the AN dynamic-range adaptation to context level that prevents information loss. While deactivating 70% of ANs or halving the endo-cochlear potential led to little SRT inflation, SRTs significantly rose as a result of total outer haircells knockout. 90% deafferentation was required to reflect performance found in hearing impaired listeners, a finding consistent with the expected effect of stochastic under-sampling [2]. ITD discrimination thresholds were found to be more sensitive to deafferentation than SRTs.

Item Type:	Conference or Workshop Item (Paper)
Date Type:	Published Online
Status:	Published
Schools:	Psychology
Subjects:	B Philosophy. Psychology. Religion > BF Psychology Q Science > QP Physiology R Medicine > RB Pathology R Medicine > RF Otorhinolaryngology
Publisher:	e-Forum Acusticum 2020
Funders:	EPSRC
Date of First Compliant Deposit:	29 January 2021
Date of Acceptance:	10 December 2020
Last Modified:	06 Nov 2024 14:30
URI:	https://orca.cardiff.ac.uk/id/eprint/138058

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