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Decoding the auditory nerve to simulate sensorineural pathologies and help refine their diagnosis

Grange, Jacques ORCID: and Culling, John ORCID: 2020. Decoding the auditory nerve to simulate sensorineural pathologies and help refine their diagnosis. Presented at: Forum Acusticum 2020 (e-FA), Virtual (Lyon, France), 7-11 December 2020. Forum Acusticum 2020 Proceedings. e-Forum Acusticum 2020,
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Pathologies underlying sensorineural hearing loss (SNHL) cannot yet be differentially diagnosed. An advanced SNHL simulator takes the stimulus encoding by Meddis and colleagues’ Model of the Auditory Periphery [1] at the auditory nerve (AN) level and decodes it into a signal used in psychophysical tasks to determine the signatures of specific pathologies. Speech reception thresholds (SRTs) for stimuli processed through the normal-hearing (NH) simulator, were just 1 dB higher than those obtained for unprocessed stimuli. With both efferent reflexes disabled, SRTs grew by ~4 dB. Simulated rate-level functions illustrate how efferent reflexes enable the AN dynamic-range adaptation to context level that prevents information loss. While deactivating 70% of ANs or halving the endo-cochlear potential led to little SRT inflation, SRTs significantly rose as a result of total outer haircells knockout. 90% deafferentation was required to reflect performance found in hearing impaired listeners, a finding consistent with the expected effect of stochastic under-sampling [2]. ITD discrimination thresholds were found to be more sensitive to deafferentation than SRTs.

Item Type: Conference or Workshop Item (Paper)
Status: In Press
Schools: Psychology
Subjects: B Philosophy. Psychology. Religion > BF Psychology
Q Science > QP Physiology
R Medicine > RB Pathology
R Medicine > RF Otorhinolaryngology
Publisher: e-Forum Acusticum 2020
Funders: EPSRC
Date of First Compliant Deposit: 29 January 2021
Date of Acceptance: 10 December 2020
Last Modified: 27 Nov 2022 13:16

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